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A segregating human allele of <i>SPO11</i> modeled in mice disrupts timing and amounts of meiotic recombination, causing oligospermia and a decreased ovarian reserve

2019-03-28

Abstract excerpt

<h4>ABSTRACT</h4> A major challenge in medical genetics is to characterize variants of unknown significance (VUS), so as to better understand underlying causes of disease and design customized treatments. Infertility has presented an especially difficult challenge with respect to not only determining if a given patient has a genetic basis, but also to identify the causative genetic factor(s). Though genome sequen...

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Literature Corpus work
52ad25b2-ad7b-54a5-8812-7d23121bb162
DOI
10.1101/592576
Open publication

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