Article
Insights into variation in meiosis from 31,228 human sperm genomes.
Nature - 1 Jul 2020
Bell Avery Davis, Mello Curtis J, Nemesh James, Brumbaugh Sara A, Wysoker Alec, McCarroll Steven A
Abstract excerpt
Meiosis, although essential for reproduction, is also variable and error-prone: rates of chromosome crossover vary among gametes, between the sexes, and among humans of the same sex, and chromosome missegregation leads to abnormal chromosome numbers (aneuploidy)1-8. To study diverse meiotic outcomes and how they covary across chromosomes, gametes and humans, we developed Sperm-seq, a way of simultaneously...
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