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A genome-wide atlas of meiotic recombination intermediates reveals distinct modes of DNA repair that direct crossovers away from transcriptionally marked genes

2026-03-28

Abstract excerpt

Crossovers are essential for accurate chromosome segregation in meiosis. Yet the programmed DNA double-strand breaks that initiate them frequently occur in genes and pose a risk to transcription required for gametogenesis. How meiotic cells reconcile these competing demands has remained unclear. Here, we generate a genome-wide in vivo atlas of meiotic recombination intermediates across ∼42,000 hotspots by mapping...

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Literature Corpus work
87e88de7-0938-5327-8c9e-bafe94599428
DOI
10.64898/2026.03.26.714455
Open publication

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A genome-wide atlas of meiotic recombination intermediates reveals distinct modes of DNA repair that direct crossovers away from transcriptionally marked genesDOI 10.64898/2026.03.26.714455
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