Article

Genotype-specific differences in infertile men due to loss-of-function variants in<i>M1AP</i>or<i>ZZS</i>genes

2024-03-22

Abstract excerpt

Male infertility and meiotic arrest have been linked to M1AP , the gene encoding meiosis I associated protein. In mice, M1AP interacts with the ZZS proteins SHOC1, TEX11, and SPO16, which promote DNA class I crossover formation during meiosis. To determine whether M1AP and ZZS proteins are involved in human male infertility by disrupting class I crossover formation, we screened for biallelic or hemizygous loss-of-...

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Literature Corpus work: 2c912213-d25b-5efb-a2cf-cf37055201bd
DOI: 10.1101/2024.03.20.24304490

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