Article

Insights about variation in meiosis from 31,228 human sperm genomes

2019-05-02

Abstract excerpt

Meiosis, while critical for reproduction, is also highly variable and error prone: crossover rates vary among humans and individual gametes, and chromosome nondisjunction leads to aneuploidy, a leading cause of miscarriage. To study variation in meiotic outcomes within and across individuals, we developed a way to sequence many individual sperm genomes at once. We used this method to sequence the genomes of 31,228...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5b2c7259-54b7-5f6f-93bc-68daf3b50cde
DOI: 10.1101/625202

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Insights about variation in meiosis from 31,228 human sperm genomesDOI 10.1101/625202Read

Insights into variation in meiosis from 31,228 human sperm genomes.Semantic proximity Read

Common variation in meiosis genes shapes human recombination and aneuploidy.Semantic proximity Read

Common variation in meiosis genes shapes human recombination phenotypes and aneuploidy riskSemantic proximity Read

Aberrant landscapes of maternal meiotic crossovers contribute to aneuploidies in human embryosSemantic proximity Read

Insights into non-crossover recombination from long-read sperm sequencingSemantic proximity Read

Genome-wide maps of recombination and chromosome segregation in human oocytes and embryos show selection for maternal recombination rates.Semantic proximity Read

Sex differences in the genetic basis of human recombination within 190,000 parent-child pairsSemantic proximity Read

High-resolution mapping of crossovers reveals extensive variation in fine-scale recombination patterns among humans.Semantic proximity Read

Genetic analysis of variation in human meiotic recombination.Semantic proximity Read

A method for low-coverage single-gamete sequence analysis demonstrates adherence to Mendel's first law across a large sample of human sperm.Semantic proximity Read

Strict adherence to Mendel’s First Law across a large sample of human sperm genomesSemantic proximity Read

Meiotic recombination hot spots and human DNA diversity.Semantic proximity Read