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Article

The fission yeast FANCM ortholog directs non-crossover recombination during meiosis.

Science (New York, N.Y.) - 22 Jun 2012

Lorenz Alexander, Osman Fekret, Sun Weili, Nandi Saikat, Steinacher Roland, Whitby Matthew C

Abstract excerpt

The formation of healthy gametes depends on programmed DNA double-strand breaks (DSBs), which are each repaired as a crossover (CO) or non-crossover (NCO) from a homologous template. Although most of these DSBs are repaired without giving COs, little is known about the genetic requirements of NCO-specific recombination. We show that Fml1, the Fanconi anemia complementation group M (FANCM)-ortholog of...

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Share to Chromosome Segregation
Share to Chromosomes, Fungal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Crossing Over, Genetic

Share to DNA Breaks, Double-Stranded

Share to Endonucleases

Share to Homologous Recombination

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Share to Schizosaccharomyces pombe Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 22723423
DOI: 10.1126/science.1220111
PMCID: PMC3399777

Genes

FANCM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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The fission yeast FANCM ortholog directs non-crossover recombination during meiosis.PMID 22723423Read ↗

FANCM-associated proteins MHF1 and MHF2, but not the other Fanconi anemia factors, limit meiotic crossovers.Semantic proximity Read ↗

The Fanconi anemia ortholog FANCM ensures ordered homologous recombination in both somatic and meiotic cells in Arabidopsis.Semantic proximity Read ↗

The FANCM ortholog Fml1 promotes recombination at stalled replication forks and limits crossing over during DNA double-strand break repair.Semantic proximity Read ↗

From meiosis to postmeiotic events: Uncovering the molecular roles of the meiosis‐specific recombinase Dmc1Semantic proximity Read ↗

FIGNL1-FIRRM is essential for meiotic recombination and prevents DNA damage-independent RAD51 and DMC1 loadingSemantic proximity Read ↗

<i>Fancm</i> regulates meiotic double-strand break repair pathway choice in mammalsSemantic proximity Read ↗

Arabidopsis thaliana FANCD2 Promotes Meiotic Crossover Formation.Semantic proximity Read ↗

The FIGNL1-FIRRM complex is required to complete meiotic recombination in the mouse and prevents massive DNA damage-independent RAD51 and DMC1 loadingSemantic proximity Read ↗

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AAA-ATPase FIDGETIN-LIKE 1 and Helicase FANCM Antagonize Meiotic Crossovers by Distinct Mechanisms.Semantic proximity Read ↗

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