Article
Common variation in meiosis genes shapes human recombination and aneuploidy.
Nature - 1 Mar 2026
Carioscia Sara A, Biddanda Arjun, Starostik Margaret R, Tang Xiaona, Hoffmann Eva R, Demko Zachary P, McCoy Rajiv C
Abstract excerpt
The leading cause of human pregnancy loss is aneuploidy, often tracing to errors in chromosome segregation during female meiosis1,2. Although abnormal crossover recombination is known to confer risk for aneuploidy3,4, limited data have hindered understanding of the potential shared genetic basis of these key molecular phenotypes. To address this gap, we performed retrospective analysis of pre-implantation genetic...
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