Predicting accumulation and age at onset of amyloid-β from genetic risk and resilience for Alzheimer’s disease

Abstract excerpt

<title>Abstract</title> <p> Accumulation of brain amyloid beta (Aβ) is a key pathological hallmark of Alzheimer’s disease (AD) and begins many years before cognitive symptoms. Being able to predict the risk of Aβ accumulation, or the age at which this accumulation exceeds a critical threshold, may enable early intervention and treatment to slow or prevent the onset of AD. We utilised published genome-wide associ...

Topics

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• Amyloid beta-Peptides
• Age of Onset
• Aged
• Alzheimer Disease
• Genetic Risk Score
• Genome-Wide Association Study
• Multifactorial Inheritance
• Risk Factors

Identifiers and source

Literature Corpus work

98df63f4-1ba3-521e-a6f3-3b9e59104b72

DOI

10.21203/rs.3.rs-7911284/v1