Article
Predicting accumulation and age at onset of amyloid-β from genetic risk and resilience for Alzheimer's disease.
EBioMedicine - 1 Jul 2026
O'Brien Eleanor K, Cox Timothy, Fernandez Shane, Bourgeat Pierrick, Porter Tenielle, Goudey Ben, Doecke James D, Masters Colin L, Fripp Jurgen, Nho Kwangsik, Villemagne Victor L, Cruchaga Carlos, Rowe Christopher C, Saykin Andrew J, Doré Vincent, Laws Simon M
Abstract excerpt
BACKGROUND: Accumulation of brain amyloid beta (Aβ), a key pathological hallmark of Alzheimer's disease (AD), begins decades before cognitive symptoms. Being able to predict the risk of Aβ accumulation, or the age at which Aβ exceeds a critical threshold, may enable intervention to delay or prevent onset of AD. METHODS: Using published genome-wide association studies (GWASs), we developed polygenic scores (PGS)...
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