Article

Multivariate blood biomarkers capture resilience and resistance phenotypes across the Alzheimer’s disease spectrum

2026-08-05

Abstract excerpt

Alzheimer’s disease pathology and cognitive outcomes frequently diverge, yet current single-axis definitions cannot identify resilient (high pathology, preserved cognition) and resistant (high risk, low pathology) subgroups reliably at scale, obscuring the mechanisms that uncouple pathological burden from cognitive decline. Here, we developed a multivariate blood-based framework integrating 19 molecular assays and...

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Literature Corpus work: 5aaebe56-fc77-51f2-b937-05442d712de7
DOI: 10.64898/2026.08.03.26359415

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