Article
Sex differences in the genetic architecture of cognitive resilience to Alzheimer's disease.
Brain : a journal of neurology - 29 Jul 2022
Eissman Jaclyn M, Dumitrescu Logan, Mahoney Emily R, Smith Alexandra N, Mukherjee Shubhabrata, Lee Michael L, Scollard Phoebe, Choi Seo Eun, Bush William S, Engelman Corinne D, Lu Qiongshi, Fardo David W, Trittschuh Emily H, Mez Jesse, Kaczorowski Catherine C, Hernandez Saucedo Hector, Widaman Keith F, Buckley Rachel F, Properzi Michael J, Mormino Elizabeth C, Yang Hyun Sik, Harrison Theresa M, Hedden Trey, Nho Kwangsik, Andrews Shea J, Tommet Douglas, Hadad Niran, Sanders R Elizabeth, Ruderfer Douglas M, Gifford Katherine A, Zhong Xiaoyuan, Raghavan Neha S, Vardarajan Badri N, Pericak-Vance Margaret A, Farrer Lindsay A, Wang Li San, Cruchaga Carlos, Schellenberg Gerard D, Cox Nancy J, Haines Jonathan L, Keene C Dirk, Saykin Andrew J, Larson Eric B, Sperling Reisa A, Mayeux Richard, Cuccaro Michael L, Bennett David A, Schneider Julie A, Crane Paul K, Jefferson Angela L, Hohman Timothy J
Abstract excerpt
Approximately 30% of elderly adults are cognitively unimpaired at time of death despite the presence of Alzheimer's disease neuropathology at autopsy. Studying individuals who are resilient to the cognitive consequences of Alzheimer's disease neuropathology may uncover novel therapeutic targets to treat Alzheimer's disease. It is well established that there are sex differences in response to Alzheimer's disease...
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