A polygenic resilience score moderates the genetic risk for schizophrenia.

doi:10.1038/s41380-019-0463-8

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Article

A polygenic resilience score moderates the genetic risk for schizophrenia.

Molecular psychiatry - 1 Mar 2021

Hess Jonathan L, Tylee Daniel S, Mattheisen Manuel, Børglum Anders D, Als Thomas D, Grove Jakob, Werge Thomas, Mortensen Preben Bo, Mors Ole, Nordentoft Merete, Hougaard David M, Byberg-Grauholm Jonas, Bækvad-Hansen Marie, Greenwood Tiffany A, Tsuang Ming T, Curtis David, Steinberg Stacy, Sigurdsson Engilbert, Stefánsson Hreinn, Stefánsson Kári, Edenberg Howard J, Holmans Peter, Faraone Stephen V, Glatt Stephen J

Abstract excerpt

Based on the discovery by the Resilience Project (Chen R. et al. Nat Biotechnol 34:531-538, 2016) of rare variants that confer resistance to Mendelian disease, and protective alleles for some complex diseases, we posited the existence of genetic variants that promote resilience to highly heritable polygenic disorders1,0 such as schizophrenia. Resilience has been traditionally viewed as a psychological construct,...

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PMID: 31492941
DOI: 10.1038/s41380-019-0463-8
PMCID: PMC7058518

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