Article

Interactome INSIDER: a multi-scale structural interactome browser for genomic studies

2017-04-12

Abstract excerpt

<h4>ABSTRACT</h4> Protein interactions underlie nearly all known cellular function, making knowledge of their binding conformations paramount to understanding the physical workings of the cell. Studying binding conformations has allowed scientists to explore some of the mechanistic underpinnings of disease caused by disruption of protein interactions. However, since experimentally determined interaction structure...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f8f9b4fb-0cd6-571c-b430-087217c92e65
DOI: 10.1101/126862

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Interactome INSIDER: a multi-scale structural interactome browser for genomic studiesDOI 10.1101/126862Read

Interactome INSIDER: a structural interactome browser for genomic studies.Semantic proximity Read

Three-dimensional reconstruction of protein networks provides insight into human genetic disease.Semantic proximity Read

A structurally informed human protein-protein interactome reveals proteome-wide perturbations caused by disease mutations.Semantic proximity Read

Protein domain-based structural interfaces help interpret biologically-relevant interactions in the human interaction networkSemantic proximity Read

Comprehensive characterization of protein-protein interaction network perturbations by human disease mutationsSemantic proximity Read

Integrating structural homology with deep learning to achieve highly accurate protein-protein interface prediction for the human interactomeSemantic proximity Read

Towards a structurally resolved human protein interaction network.Semantic proximity Read

Towards a structurally resolved human protein interaction networkSemantic proximity Read

The properties of human disease mutations at protein interfacesSemantic proximity Read

Comprehensive Atomic-Scale 3D Viral-Host Protein Interactomes Enable Dissection of Key Mechanisms and Evolutionary Processes Underlying Viral PathogenesisSemantic proximity Read

Towards a structurally resolved human protein interaction networkSemantic proximity Read

Structurally-informed human interactome reveals proteome-wide perturbations by disease mutationsSemantic proximity Read