Article

Integrating structural homology with deep learning to achieve highly accurate protein-protein interface prediction for the human interactome

2025-06-12

Abstract excerpt

A significant portion of disease-causing mutations occur at protein-protein interfaces however, the number of structurally resolved multi-protein complexes is extremely small. Here we present a computational pipeline, PIONEER2.0, that integrates 3D structural similarity with geometric deep learning to accurately predict protein binding partner-specific interfacial residues for all experimentally observed human bin...

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Literature Corpus work: d17a41ab-88f6-5d11-9494-8f0368b7c5b2
DOI: 10.1101/2025.06.09.658393

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