Article
Towards a structurally resolved human protein interaction network.
Nature structural & molecular biology - 1 Feb 2023
Burke David F, Bryant Patrick, Barrio-Hernandez Inigo, Memon Danish, Pozzati Gabriele, Shenoy Aditi, Zhu Wensi, Dunham Alistair S, Albanese Pascal, Keller Andrew, Scheltema Richard A, Bruce James E, Leitner Alexander, Kundrotas Petras, Beltrao Pedro, Elofsson Arne
Abstract excerpt
Cellular functions are governed by molecular machines that assemble through protein-protein interactions. Their atomic details are critical to studying their molecular mechanisms. However, fewer than 5% of hundreds of thousands of human protein interactions have been structurally characterized. Here we test the potential and limitations of recent progress in deep-learning methods using AlphaFold2 to predict...
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