Article

Towards a structurally resolved human protein interaction network

2021-11-09

Abstract excerpt

All cellular functions are governed by complex molecular machines that assemble through protein-protein interactions. Their atomic details are critical to the study of their molecular mechanisms but fewer than 5% of hundreds of thousands of human interactions have been structurally characterized. Here, we test the potential and limitations of recent progress in deep-learning methods using AlphaFold2 to predict str...

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Literature Corpus work: e7648544-1fe7-5cb1-9215-075b66a23e09
DOI: 10.1101/2021.11.08.467664

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