Article

Comprehensive characterization of protein-protein interaction network perturbations by human disease mutations

2020-09-21

Abstract excerpt

Technological and computational advances in genomics and interactomics have made it possible to identify rapidly how disease mutations perturb interaction networks within human cells. In this study, we investigate at large-scale the effects of network perturbations caused by disease mutations within the human three-dimensional (3D), structurally-resolved macromolecular interactome. We show that disease-associated...

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Literature Corpus work: e39b89d9-5e45-59a3-a12f-c0b261368256
DOI: 10.1101/2020.09.18.302588

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