Article
Three-dimensional reconstruction of protein networks provides insight into human genetic disease.
Nature biotechnology - 15 Jan 2012
Wang Xiujuan, Wei Xiaomu, Thijssen Bram, Das Jishnu, Lipkin Steven M, Yu Haiyuan
Abstract excerpt
To better understand the molecular mechanisms and genetic basis of human disease, we systematically examine relationships between 3,949 genes, 62,663 mutations and 3,453 associated disorders by generating a three-dimensional, structurally resolved human interactome. This network consists of 4,222 high-quality binary protein-protein interactions with their atomic-resolution interfaces. We find that in-frame...
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