Structurally-informed human interactome reveals proteome-wide perturbations by disease mutations

Abstract excerpt

Human genome sequencing studies have identified numerous loci associated with complex diseases. However, translating human genetic and genomic findings to disease pathobiology and therapeutic discovery remains a major challenge at multiscale interactome network levels. Here, we present a deep-learning-based ensemble framework, termed PIONEER ( P rotein-protein I nteracti O n i N t E rfac E p R ediction), th...

Topics

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• Deep Learning
• Mutation
• Neoplasms
• Protein Binding
• Protein Interaction Mapping
• Protein Interaction Maps
• Proteome
• Software

Identifiers and source

Literature Corpus work

cdaa70ab-0378-5381-a5be-d8e414b776cc

DOI

10.1101/2023.04.24.538110