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Article

Interactome INSIDER: a structural interactome browser for genomic studies.

Nature methods - 1 Feb 2018

Meyer Michael J, Beltrán Juan Felipe, Liang Siqi, Fragoza Robert, Rumack Aaron, Liang Jin, Wei Xiaomu, Yu Haiyuan

Abstract excerpt

We present Interactome INSIDER, a tool to link genomic variant information with structural protein-protein interactomes. Underlying this tool is the application of machine learning to predict protein interaction interfaces for 185,957 protein interactions with previously unresolved interfaces in human and seven model organisms, including the entire experimentally determined human binary interactome. Predicted...

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PMID: 29355848
DOI: 10.1038/nmeth.4540
PMCID: PMC6026581

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