Article

Protein domain-based structural interfaces help interpret biologically-relevant interactions in the human interaction network

2020-03-16

Abstract excerpt

A high-quality map of the human protein–protein interaction (PPI) network can help us better understand complex genotype–phenotype relationships. Each edge between two interacting proteins supported through an interface in a three-dimensional (3D) structure of a protein complex adds credibility to the biological relevance of the interaction. Such structure-supported interactions would augment an interaction map pr...

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Literature Corpus work: f8ef0c01-668d-501b-a5f3-1f80c2499e35
DOI: 10.1101/2020.03.14.992149

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