Article

The properties of human disease mutations at protein interfaces

2021-08-21

Abstract excerpt

The assembly of proteins into complexes and interactions with other biomolecules are often vital for their biological function. While it is known that mutations at protein interfaces have a high potential to be damaging and cause human genetic disease, there has been relatively little consideration for how this varies between different types of interfaces. Here we investigate the properties of human pathogenic and...

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Literature Corpus work: 4672aa65-d839-535e-a710-00a4468502bb
DOI: 10.1101/2021.08.20.457107

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