Enhanced ISGylation reduces respiratory distress following <i>Francisella novicida</i> infection

Abstract excerpt

The Interferon-Stimulated Gene 15 (ISG15) is a ubiquitin-like protein induced by viral and bacterial infection. ISG15 covalently modifies host and pathogenic proteins in a process called ISGylation. Yet, the consequences of ISGylation on protein fate and function remain to be determined. Here we sought to assess whether ISGylation would be protective following bacterial pneumonia caused by Francisella novicida. W...

Topics

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• Cell Adhesion Molecules Research
• Cytokine Signaling Pathways and Interactions
• Cytomegalovirus and herpesvirus research
• interferon and immune responses
• Mosquito-borne diseases and control
• Neutrophil, Myeloperoxidase and Oxidative Mechanisms
• RNA regulation and disease
• Ubiquitin and proteasome pathways

Identifiers and source

Literature Corpus work

f88c6c59-d788-5e31-a94b-bdf075657f98

DOI

10.1101/2023.09.19.558558