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Article

Dysregulation of innate immunity and cellular metabolism through virus-induced deISGylation

2025-09-09

Abstract excerpt

<h4>SUMMARY</h4> Interferon-stimulated gene 15 (ISG15) regulates diverse cellular responses including antiviral immunity through its conjugation to proteins, a process known as ISGylation. Several pathogens, including SARS-CoV-2, subvert ISGylation by encoding deISGylating enzymes. However, the direct targets and physiological consequences of coronaviral deISGylation remain poorly defined. Here, we ablated the de...

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Identifiers and source

Literature Corpus work
049982e2-e798-567d-8b2f-cc7f45712cc1
DOI
10.1101/2025.09.08.674928
Open publication

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Dysregulation of innate immunity and cellular metabolism through virus-induced deISGylationDOI 10.1101/2025.09.08.674928
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