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Article

ISGylation in Innate Antiviral Immunity and Pathogen Defense Responses: A Review

25 Nov 2021

Abstract excerpt

The interferon-stimulating gene 15 (ISG15) protein is a ubiquitin-like protein induced by interferons or pathogens. ISG15 can exist in free form or covalently bind to the target protein through an enzymatic cascade reaction, which is called ISGylation. ISGylation has been found to play an important role in the innate immune responses induced by type I interferon, and is, thus, critical for the defense of host...

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PMID: 34901029
DOI: 10.3389/fcell.2021.788410

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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