Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ISG15: leading a double life as a secreted molecule

12 Apr 2013

Abstract excerpt

ISG15 is a well-known intracellular ubiquitin-like molecule involved in ISGylation. However, a recent study has revived the notion first put forward two decades ago that ISG15 is also a secreted molecule. Human neutrophils, monocytes and lymphocytes can release ISG15, even though this protein has no detectable signal peptide sequence. ISG15 has also been found in the secretory granules of granulocytes. The...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Adhesion Molecules Research
Share to interferon and immune responses
Share to Neutrophil, Myeloperoxidase and Oxidative Mechanisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23579383
DOI: 10.1038/emm.2013.36

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ISG15: leading a double life as a secreted moleculePMID 23579383Read ↗

Mycobacterial Disease and Impaired IFN-γ Immunity in Humans with Inherited ISG15 DeficiencySemantic proximity Read ↗

Human intracellular ISG15 prevents interferon-α/β over-amplification and auto-inflammation.Semantic proximity Read ↗

ISG-15, beyond its functions in the cell: a mini reviewSemantic proximity Read ↗

ISG15 and ISGylation in Human DiseasesSemantic proximity Read ↗

The diverse repertoire of ISG15: more intricate than initially thoughtSemantic proximity Read ↗

ISG15 deficiency and increased viral resistance in humans but not miceSemantic proximity Read ↗

Emerging Roles for Immunomodulatory Functions of Free ISG15Semantic proximity Read ↗

Altered ISGylation drives aberrant macrophage-dependent immune responses during SARS-CoV-2 infectionSemantic proximity Read ↗

ISG15 driven cellular responses to virus infectionSemantic proximity Read ↗

ISGylation in Innate Antiviral Immunity and Pathogen Defense Responses: A ReviewSemantic proximity Read ↗

Extracellular ISG15 triggers ISGylation via a type-I interferon independent non-canonical mechanism to regulate host response during virus infectionSemantic proximity Read ↗

A co-opted ISG15-USP18 binding mechanism normally reserved for deISGylation controls type I IFN signallingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.