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Article

ISG15 facilitates cellular antiviral response to dengue and west nile virus infection in vitro

13 Oct 2011

Abstract excerpt

BACKGROUND: Dengue virus (DENV) and West Nile virus (WNV), close siblings of the Flaviviridae family, are the causative agents of Dengue hemorraghic shock or West Nile meningoencephalitis respectively. Vaccines against these two flaviviruses are currently unavailable. Interferon- Stimulated Gene 15 (ISG15), encoding an ubiquitin-like protein, is significantly induced by type I interferons or viral infections. Its...

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PMID: 21992229
DOI: 10.1186/1743-422x-8-468

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