Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Novel Mode of ISG15-Mediated Protection against Influenza A Virus and Sendai Virus in Mice

16 Oct 2014

Abstract excerpt

UNLABELLED: ISG15 is a diubiquitin-like modifier and one of the most rapidly induced genes upon type I interferon stimulation. Hundreds of host proteins and a number of viral proteins have been shown to be ISGylated, and understanding how these modifications affect the interferon response and virus replication has been of considerable interest. ISG15(-/-) mice exhibit increased susceptibility to viral infection,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Herpesvirus Infections and Treatments
Share to interferon and immune responses
Share to RNA regulation and disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 25320315
DOI: 10.1128/jvi.02110-14

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Novel Mode of ISG15-Mediated Protection against Influenza A Virus and Sendai Virus in MicePMID 25320315Read ↗

IFN-stimulated gene 15 functions as a critical antiviral molecule against influenza, herpes, and Sindbis virusesSemantic proximity Read ↗

ISGylation in Innate Antiviral Immunity and Pathogen Defense Responses: A ReviewSemantic proximity Read ↗

ISG15 driven cellular responses to virus infectionSemantic proximity Read ↗

ISG15 facilitates cellular antiviral response to dengue and west nile virus infection in vitroSemantic proximity Read ↗

The diverse repertoire of ISG15: more intricate than initially thoughtSemantic proximity Read ↗

Altered ISGylation drives aberrant macrophage-dependent immune responses during SARS-CoV-2 infectionSemantic proximity Read ↗

ISG15: leading a double life as a secreted moleculeSemantic proximity Read ↗

ISG15 deficiency and increased viral resistance in humans but not miceSemantic proximity Read ↗

ISG15 Arg151 and the ISG15-Conjugating Enzyme UbE1L Are Important for Innate Immune Control of Sindbis VirusSemantic proximity Read ↗

ISG15: A link between innate immune signaling, DNA replication, and genome stabilitySemantic proximity Read ↗

Mycobacterial Disease and Impaired IFN-γ Immunity in Humans with Inherited ISG15 DeficiencySemantic proximity Read ↗

Extracellular ISG15 triggers ISGylation via a type-I interferon independent non-canonical mechanism to regulate host response during virus infectionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.