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Article

The diverse repertoire of ISG15: more intricate than initially thought

1 Nov 2022

Abstract excerpt

ISG15, the product of interferon (IFN)-stimulated gene 15, is the first identified ubiquitin-like protein (UBL), which plays multifaceted roles not only as a free intracellular or extracellular molecule but also as a post-translational modifier in the process of ISG15 conjugation (ISGylation). ISG15 has only been identified in vertebrates, indicating that the functions of ISG15 and its conjugation are restricted...

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PMID: 36319753
DOI: 10.1038/s12276-022-00872-3

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