Article

Altered ISGylation drives aberrant macrophage-dependent immune responses during SARS-CoV-2 infection

2020-09-10

Abstract excerpt

<title>Abstract</title> <p>Interferon stimulated gene 15 (ISG15) is a ubiquitin like modifier frequently induced during virus infections and involved in versatile host defense mechanisms. Not surprisingly, many viruses including SARS-CoV-2 have evolved de-ISGylating activities to antagonize its effect. In this study we compared ISG15-driven macrophage responses upon infection by influenza, Zika and SARS-CoV-2 vir...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1a7491f7-c831-58b6-afac-e2b76de326cc
DOI: 10.21203/rs.3.rs-63942/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Altered ISGylation drives aberrant macrophage-dependent immune responses during SARS-CoV-2 infectionDOI 10.21203/rs.3.rs-63942/v1Read

ISG15 driven cellular responses to virus infectionSemantic proximity Read

ISGylation in Innate Antiviral Immunity and Pathogen Defense Responses: A ReviewSemantic proximity Read

The diverse repertoire of ISG15: more intricate than initially thoughtSemantic proximity Read

Emerging Roles for Immunomodulatory Functions of Free ISG15Semantic proximity Read

ISG-15, beyond its functions in the cell: a mini reviewSemantic proximity Read

ISG15 and ISGylation in Human DiseasesSemantic proximity Read

ISG15, a Small Molecule with Huge Implications: Regulation of Mitochondrial HomeostasisSemantic proximity Read

ISG15: leading a double life as a secreted moleculeSemantic proximity Read

Extracellular ISG15 triggers ISGylation via a type-I interferon independent non-canonical mechanism to regulate host response during virus infectionSemantic proximity Read

USP24 is an ISG15 cross-reactive deubiquitinase that mediates IFN-I production by de-ISGylating the RNA helicase MOV10Semantic proximity Read

Dysregulation of innate immunity and cellular metabolism through virus-induced deISGylationSemantic proximity Read

ISG15 facilitates cellular antiviral response to dengue and west nile virus infection in vitroSemantic proximity Read