USP24 is an ISG15 cross-reactive deubiquitinase that mediates IFN-I production by de-ISGylating the RNA helicase MOV10

Abstract excerpt

<h4>ABSTRACT</h4> The interferon-stimulated gene 15 (ISG15) is a ubiquitin-like modifier induced by type I Interferon (IFN-I) and plays a crucial role in the innate immune response against viral infections. ISG15 is conjugated to target proteins by an enzymatic cascade through a process called ISGylation. While ubiquitin-specific protease 18 (USP18) is a well-defined deISGylase counteracting ISG15 conjugation, IS...

Topics

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• Cell Adhesion Molecules Research
• Cytokine Signaling Pathways and Interactions
• Immunotherapy and Immune Responses
• interferon and immune responses
• Peptidase Inhibition and Analysis
• RNA regulation and disease
• T-cell and B-cell Immunology
• Ubiquitin and proteasome pathways

Identifiers and source

Literature Corpus work

7da71497-f116-53fb-b18c-021d6ebc6c91

DOI

10.1101/2024.09.06.611391