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ISG15: A link between innate immune signaling, DNA replication, and genome stability

5 May 2023

Abstract excerpt

Interferon stimulated gene 15 (ISG15) encodes a ubiquitin-like protein that is highly induced upon activation of interferon signaling and cytoplasmic DNA sensing pathways. As part of the innate immune system ISG15 acts to inhibit viral replication and particle release via the covalent conjugation to both viral and host proteins. Unlike ubiquitin, unconjugated ISG15 also functions as an intracellular and...

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PMID: 37147792
DOI: 10.1002/bies.202300042

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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