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Article

From genes to pain: nerve growth factor and hereditary sensory and autonomic neuropathy type V.

The European journal of neuroscience - 1 Feb 2014

Capsoni Simona

Abstract excerpt

Hereditary sensory and autonomic neuropathy type V (HSAN V) is an autosomal recessive disorder characterized by the loss of deep pain perception. The anomalous pain and temperature sensations are due to the absence of nociceptive sensory innervation. The neurotrophin nerve growth factor (NGF), by binding to tropomyosin receptor A (TrkA) and p75NTR receptors, is essential for the development and survival of...

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Source

Identifiers

PMID: 24494679
DOI: 10.1111/ejn.12461

Genes

NGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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From genes to pain: nerve growth factor and hereditary sensory and autonomic neuropathy type V.PMID 24494679Read ↗

Understanding pain perception through genetic painlessness diseases: The role of NGF and proNGF.Semantic proximity Read ↗

Taking pain out of NGF: a "painless" NGF mutant, linked to hereditary sensory autonomic neuropathy type V, with full neurotrophic activity.Semantic proximity Read ↗

A novel NGF mutation clarifies the molecular mechanism and extends the phenotypic spectrum of the HSAN5 neuropathy.Semantic proximity Read ↗

Genetics of congenital insensitivity to pain with anhidrosis (CIPA) or hereditary sensory and autonomic neuropathy type IV. Clinical, biological and molecular aspects of mutations in TRKA(NTRK1) gene encoding the receptor tyrosine kinase for nerve growth factor.Semantic proximity Read ↗

A Missense Point Mutation in Nerve Growth Factor (NGF <sup>R100W</sup> ) Results in Selective Peripheral Sensory NeuropathySemantic proximity Read ↗

The NGFR100W Mutation Specifically Impairs Nociception without Affecting Cognitive Performance in a Mouse Model of Hereditary Sensory and Autonomic Neuropathy Type V.Semantic proximity Read ↗

Molecular basis of congenital insensitivity to pain with anhidrosis (CIPA): mutations and polymorphisms in TRKA (NTRK1) gene encoding the receptor tyrosine kinase for nerve growth factor.Semantic proximity Read ↗

Single-Fiber Recordings of Nociceptive Fibers in Patients With HSAN Type V With Congenital Insensitivity to Pain.Semantic proximity Read ↗

Exome sequencing identifies novel NTRK1 mutations in patients with HSAN-IV phenotype.Semantic proximity Read ↗

Swedish Nerve Growth Factor Mutation (NGF <sup>R100W</sup> ) Defines a Role for TrkA and p75NTR in NociceptionSemantic proximity Read ↗

Novel missense, insertion and deletion mutations in the neurotrophic tyrosine kinase receptor type 1 gene (NTRK1) associated with congenital insensitivity to pain with anhidrosis.Semantic proximity Read ↗

Norrbottnian congenital insensitivity to pain.Semantic proximity Read ↗

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