The NGFR100W Mutation Specifically Impairs Nociception without Affecting Cognitive Performance in a Mouse Model of Hereditary Sensory and Autonomic Neuropathy Type V.

doi:10.1523/JNEUROSCI.0688-19.2019

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Article

The NGFR100W Mutation Specifically Impairs Nociception without Affecting Cognitive Performance in a Mouse Model of Hereditary Sensory and Autonomic Neuropathy Type V.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 4 Dec 2019

Testa Giovanna, Mainardi Marco, Morelli Chiara, Olimpico Francesco, Pancrazi Laura, Petrella Carla, Severini Cinzia, Florio Rita, Malerba Francesca, Stefanov Antonia, Strettoi Enrica, Brandi Rossella, Arisi Ivan, Heppenstall Paul, Costa Mario, Capsoni Simona, Cattaneo Antonino

Abstract excerpt

Nerve growth factor (NGF) is a key mediator of nociception, acting during the development and differentiation of dorsal root ganglion (DRG) neurons, and on adult DRG neuron sensitization to painful stimuli. NGF also has central actions in the brain, where it regulates the phenotypic maintenance of cholinergic neurons. The physiological function of NGF as a pain mediator is altered in patients with Hereditary...

Topics

Animals
Behavior, Animal
Cognition
Female
Ganglia, Spinal
Gene Knock-In Techniques
Hereditary Sensory and Autonomic Neuropathies
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Mice

Mice, Transgenic

Mutation

Mutation, Missense

Nerve Growth Factor

Nociception

Pain Measurement

Pain Perception

Psychomotor Performance

Source

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Identifiers

PMID: 31685654
DOI: 10.1523/JNEUROSCI.0688-19.2019
PMCID: PMC6891056

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