Article

Comparative single-cell lineage bias in human and murine hematopoietic stem cells

2024-11-19

Abstract excerpt

The commitment of hematopoietic stem cells (HSC) to myeloid, erythroid, and lymphoid lineages is influenced by microenvironmental cues, and governed by cell-intrinsic and epigenetic characteristics that are unique to the HSC population. To investigate the nature of lineage commitment bias in human HSC, mitochondrial single cell (sc) ATAC-Sequencing (mt-scATAC-Seq) was used to identify somatic mutations in mitochon...

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Literature Corpus work: f7e3f0b1-d387-5635-9013-a25e4144b4f7
DOI: 10.1101/2024.11.19.624262

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