Reconstructing the Lineage Histories and Differentiation Trajectories of Individual Cancer Cells in Myeloproliferative Neoplasms.

doi:10.1016/j.stem.2021.02.001

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Reconstructing the Lineage Histories and Differentiation Trajectories of Individual Cancer Cells in Myeloproliferative Neoplasms.

Cell stem cell - 4 Mar 2021

Van Egeren Debra, Escabi Javier, Nguyen Maximilian, Liu Shichen, Reilly Christopher R, Patel Sachin, Kamaz Baransel, Kalyva Maria, DeAngelo Daniel J, Galinsky Ilene, Wadleigh Martha, Winer Eric S, Luskin Marlise R, Stone Richard M, Garcia Jacqueline S, Hobbs Gabriela S, Camargo Fernando D, Michor Franziska, Mullally Ann, Cortes-Ciriano Isidro, Hormoz Sahand

Abstract excerpt

Some cancers originate from a single mutation event in a single cell. Blood cancers known as myeloproliferative neoplasms (MPNs) are thought to originate when a driver mutation is acquired by a hematopoietic stem cell (HSC). However, when the mutation first occurs in individuals and how it affects the behavior of HSCs in their native context is not known. Here we quantified the effect of the JAK2-V617F mutation...

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Identifiers

PMID: 33621486
DOI: 10.1016/j.stem.2021.02.001
PMCID: PMC7939520

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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