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Article

Dynamics of clonal hematopoiesis and cellular responses to stress-induced toxicity in autologous stem cell transplantation.

Leukemia - 1 Feb 2026

Stein Catarina M, Hablesreiter Raphael, Christen Friederike, Löwe Pelle, Fustero-Torre Coral, Kopp Klara, Locher Benjamin N, Nitsch Lena, Altwasser Robert, Kerschbaum Johanna Franziska, Bullinger Lars, Ludwig Leif S, Strzelecka Paulina M, Damm Frederik

Abstract excerpt

Autologous stem cell transplantation (ASCT) involves harvesting hematopoietic stem and progenitor cells (HSPCs) prior to chemotherapy and subsequent repopulation of the bone marrow. This process imposes a bottleneck, providing a framework to dissect the unresolved short- and long-term clonal dynamics during hematopoietic reconstitution. By integrating bulk error-corrected targeted sequencing of clonal...

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Share to Clonal Evolution
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Lymphoma, Non-Hodgkin

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Identifiers

PMID: 41419602
DOI: 10.1038/s41375-025-02823-z
PMCID: PMC12875865

Genes

DNMT3A

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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