Article
Accumulating mitochondrial DNA mutations drive premature hematopoietic aging phenotypes distinct from physiological stem cell aging.
Cell stem cell - 6 May 2011
Norddahl Gudmundur L, Pronk Cornelis J, Wahlestedt Martin, Sten Gerd, Nygren Jens M, Ugale Amol, Sigvardsson Mikael, Bryder David
Abstract excerpt
Somatic stem cells mediate tissue maintenance for the lifetime of an organism. Despite the well-established longevity that is a prerequisite for such function, accumulating data argue for compromised stem cell function with age. Identifying the mechanisms underlying age-dependent stem cell dysfunction is therefore key to understanding the aging process. Here, using a model carrying a proofreading-defective...
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