Tracking Rare Single Donor and Recipient Immune and Leukemia Cells after Allogeneic Hematopoietic Cell Transplantation Using Mitochondrial DNA Mutations.

doi:10.1158/2643-3230.BCD-23-0138

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Tracking Rare Single Donor and Recipient Immune and Leukemia Cells after Allogeneic Hematopoietic Cell Transplantation Using Mitochondrial DNA Mutations.

Blood cancer discovery - 1 Nov 2024

Penter Livius, Cieri Nicoletta, Maurer Katie, Kwok Marwan, Lyu Haoxiang, Lu Wesley S, Oliveira Giacomo, Gohil Satyen H, Leshchiner Ignaty, Lareau Caleb A, Ludwig Leif S, Neuberg Donna S, Kim Haesook T, Li Shuqiang, Bullinger Lars, Ritz Jerome, Getz Gad, Garcia Jacqueline S, Soiffer Robert J, Livak Kenneth J, Wu Catherine J

Abstract excerpt

Combined tracking of clonal evolution and chimeric cell phenotypes could enable detection of the key cellular populations associated with response following therapy, including after allogeneic hematopoietic stem cell transplantation (HSCT). We demonstrate that mitochondrial DNA (mtDNA) mutations coevolve with somatic nuclear DNA mutations at relapse post-HSCT and provide a sensitive means to monitor these...

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PMID: 39236287
DOI: 10.1158/2643-3230.BCD-23-0138
PMCID: PMC11528187

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