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The Biology of Hematopoietic Stem Cells

1 Nov 1995

Abstract excerpt

Hematopoietic stem cells (HSC) are the only cells in the blood-forming tissues that can give rise to all blood cell types and that can self-renew to produce more HSC. In mouse and human, HSC represent up to 0.05% of cells in the bone marrow. HSC are almost entirely responsible for the radioprotective and short- and long-term reconstituting effects observed after bone marrow transplantation. The subsets of HSC...

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PMID: 8689561
DOI: 10.1146/annurev.cb.11.110195.000343

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