Article

The TCRs of pathogenic Th17 cells in arthritogenic mice are shifted toward a Treg-like repertoire

2024-03-04

Abstract excerpt

<h4>Summary</h4> Mutations in the ZAP-70 gene that cause moderate attenuation of T cell receptor (TCR) signaling in mice can result in autoimmune manifestations. One explanation for this pathology is a shift in the regulatory-conventional (Treg-Tconv) T cell repertoire composition. To test this hypothesis, we characterized the single-cell gene expression profiles and TCR repertoires of Tconv and Treg CD4+ T cells...

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Literature Corpus work: f7cd3513-3b4a-51d7-bee2-c544e5947289
DOI: 10.1101/2024.03.01.582868

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