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Article

Single-cell gene expression reveals a landscape of regulatory T cell phenotypes shaped by the TCR.

Nature immunology - 1 Mar 2018

Zemmour David, Zilionis Rapolas, Kiner Evgeny, Klein Allon M, Mathis Diane, Benoist Christophe

Abstract excerpt

CD4+ T regulatory cells (Treg) are central to immune homeostasis, their phenotypic heterogeneity reflecting the diverse environments and target cells that they regulate. To understand this heterogeneity, we combined single-cell RNA-seq, activation reporter and T cell receptor (TCR) analysis to profile thousands of Treg or conventional CD4+FoxP3- T cells (Tconv) from mouse lymphoid organs and human blood. Treg and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29434354
DOI: 10.1038/s41590-018-0051-0
PMCID: PMC6069633

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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