Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A disease-associated mutation that weakens ZAP70 autoinhibition enhances responses to weak and self-ligands.

Science signaling - 2 Feb 2021

Shen Lin, Matloubian Mehrdad, Kadlecek Theresa A, Weiss Arthur

Abstract excerpt

The cytoplasmic kinase ZAP70 is critical for T cell antigen receptor (TCR) signaling. The R360P mutation in ZAP70 is responsible for an early-onset familial autoimmune syndrome. The structural location and biochemical signaling effects of the R360P mutation are consistent with weakening of the autoinhibitory conformation of ZAP70. Mice with a ZAP70 R360P mutation and polyclonal TCR repertoires exhibited...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autoimmune Diseases
Share to CD8-Positive T-Lymphocytes

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to HEK293 Cells

Share to Immune Tolerance

Share to Mice, Inbred C57BL

Share to Mice, Transgenic

Share to Receptors, Antigen, T-Cell

Share to ZAP-70 Protein-Tyrosine Kinase

Source

Open in PubMed Open full text

Identifiers

PMID: 33531381
DOI: 10.1126/scisignal.abc4479
PMCID: PMC8009134

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A disease-associated mutation that weakens ZAP70 autoinhibition enhances responses to weak and self-ligands.PMID 33531381Read ↗

A hypomorphic allele of ZAP-70 reveals a distinct thymic threshold for autoimmune disease versus autoimmune reactivity.Semantic proximity Read ↗

ZAP-70 in Signaling, Biology, and DiseaseSemantic proximity Read ↗

The TCRs of pathogenic Th17 cells in arthritogenic mice are shifted toward a Treg-like repertoireSemantic proximity Read ↗

A novel Zap70 mutation with reduced protein stability demonstrates the rate-limiting threshold for Zap70 in T-cell receptor signalling.Semantic proximity Read ↗

A novel human autoimmune syndrome caused by combined hypomorphic and activating mutations in ZAP-70.Semantic proximity Read ↗

Lymphocyte disturbance and functional assessment of the [Asp521Asn] ZAP70 mutation.Semantic proximity Read ↗

Inhibition of ZAP-70 kinase activity via an analog-sensitive allele blocks T cell receptor and CD28 superagonist signaling.Semantic proximity Read ↗

Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in miceSemantic proximity Read ↗

Altered thymic differentiation and modulation of arthritis by invariant NKT cells expressing mutant ZAP70.Semantic proximity Read ↗

Spontaneous development of autoimmune arthritis due to genetic anomaly of T cell signal transduction: Part 1.Semantic proximity Read ↗

LCK at the crossroad of immunodeficiency and autoimmunity: Mechanisms and therapeutic opportunities.Semantic proximity Read ↗

[Everything you ever wanted to know about ZAP-70].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.