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Article

A hypomorphic allele of ZAP-70 reveals a distinct thymic threshold for autoimmune disease versus autoimmune reactivity.

The Journal of experimental medicine - 26 Oct 2009

Hsu Lih-Yun, Tan Ying Xim, Xiao Zheng, Malissen Marie, Weiss Arthur

Abstract excerpt

ZAP-70 is critical for T cell receptor (TCR) signaling. Tyrosine to phenylalanine mutations of Y315 and Y319 in ZAP-70 suggest these residues function to recruit downstream effector molecules, but mutagenesis and crystallization studies reveal that these residues also play an important role in autoinhibition ZAP-70. To address the importance of the scaffolding function, we generated a zap70 mutant mouse (YYAA...

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Source

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Identifiers

PMID: 19841086
DOI: 10.1084/jem.20082902
PMCID: PMC2768860

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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