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Article

Altered thymic differentiation and modulation of arthritis by invariant NKT cells expressing mutant ZAP70.

Nature communications - 6 Jul 2018

Zhao Meng, Svensson Mattias N D, Venken Koen, Chawla Ashu, Liang Shu, Engel Isaac, Mydel Piotr, Day Jeremy, Elewaut Dirk, Bottini Nunzio, Kronenberg Mitchell

Abstract excerpt

Various subsets of invariant natural killer T (iNKT) cells with different cytokine productions develop in the mouse thymus, but the factors driving their differentiation remain unclear. Here we show that hypomorphic alleles of Zap70 or chemical inhibition of Zap70 catalysis leads to an increase of IFN-γ-producing iNKT cells (NKT1 cells), suggesting that NKT1 cells may require a lower TCR signal threshold. Zap70...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 29980684
DOI: 10.1038/s41467-018-05095-7
PMCID: PMC6035278

Genes

ZAP70

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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