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Article

Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice

1 Nov 2003

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Share to Immune Cell Function and Interaction
Share to Monoclonal and Polyclonal Antibodies Research
Share to T-cell and B-cell Immunology

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 14647385
DOI: 10.1038/nature02119

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in micePMID 14647385Read ↗

A hypomorphic allele of ZAP-70 reveals a distinct thymic threshold for autoimmune disease versus autoimmune reactivity.Semantic proximity Read ↗

Spontaneous development of autoimmune arthritis due to genetic anomaly of T cell signal transduction: Part 1.Semantic proximity Read ↗

The TCRs of pathogenic Th17 cells in arthritogenic mice are shifted toward a Treg-like repertoireSemantic proximity Read ↗

Altered thymic differentiation and modulation of arthritis by invariant NKT cells expressing mutant ZAP70.Semantic proximity Read ↗

The SKG Mutation in ZAP-70 also Confers Arthritis Susceptibility in C57 Black Mouse Strains.Semantic proximity Read ↗

A disease-associated mutation that weakens ZAP70 autoinhibition enhances responses to weak and self-ligands.Semantic proximity Read ↗

ZAP-70 in Signaling, Biology, and DiseaseSemantic proximity Read ↗

Distinct T Cell Developmental Consequences in Humans and Mice Expressing Identical Mutations in the DLAARN Motif of ZAP-70Semantic proximity Read ↗

Defective T cell receptor signaling and CD8+ thymic selection in humans lacking Zap-70 kinaseSemantic proximity Read ↗

Graded attenuation of TCR signaling elicits distinct autoimmune diseases by altering thymic T cell selection and regulatory T cell function.Semantic proximity Read ↗

A novel Zap70 mutation with reduced protein stability demonstrates the rate-limiting threshold for Zap70 in T-cell receptor signalling.Semantic proximity Read ↗

A novel human autoimmune syndrome caused by combined hypomorphic and activating mutations in ZAP-70.Semantic proximity Read ↗

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