Article

Single cell analysis of FOXP3 deficiencies in humans and mice unmasks intrinsic and extrinsic CD4 <sup>+</sup> T cell perturbations

2020-07-06

Abstract excerpt

<h4>ABSTRACT</h4> FOXP3 deficiency in humans with IPEX syndrome and mice results in fatal systemic autoimmunity by altering regulatory T cell (Treg) physiology, but actual cellular and molecular mechanisms of disease are unclear, part because Treg surface markers may be unreliable in disease states. We used deep profiling by flow cytometry, population and single-cell RNAseq to analyze Tregs and conventional (Tcon...

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Literature Corpus work: e4e1c735-3400-5755-8c85-c33845162569
DOI: 10.1101/2020.07.06.189589

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