Article
Graded attenuation of TCR signaling elicits distinct autoimmune diseases by altering thymic T cell selection and regulatory T cell function.
Journal of immunology (Baltimore, Md. : 1950) - 15 Aug 2010
Tanaka Satoshi, Maeda Shinji, Hashimoto Motomu, Fujimori Chihiro, Ito Yoshinaga, Teradaira Shin, Hirota Keiji, Yoshitomi Hiroyuki, Katakai Tomoya, Shimizu Akira, Nomura Takashi, Sakaguchi Noriko, Sakaguchi Shimon
Abstract excerpt
Mice with a mutation of the zeta-associated protein of 70 kDa gene (skg mutation) are genetically prone to develop autoimmune arthritis, depending on the environment. In a set of mice with the mutation, the amount of zeta-associated protein of 70 kDa protein as well as its tyrosine phosphorylation upon TCR stimulation decreased from +/+, skg/+, skg/skg, to skg/- mice in a stepwise manner. The reduction resulted...
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