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Article

Naïve arthritogenic SKG T cells have a defect in anergy and a repertoire pruned by superantigen

2022-01-16

Abstract excerpt

How autoreactive CD4 T cells develop to cause rheumatoid arthritis remains unknown. We used a reporter for antigen-receptor signaling in the SKG autoimmune arthritis model to profile a T cell subpopulation enriched for arthritogenic naïve CD4 T cells before arthritis onset by bulk and single cell RNA and T cell antigen-receptor (TCR) sequencing. Our analyses reveal that despite their impaired proximal TCR signalin...

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Identifiers and source

Literature Corpus work
3471d0c8-c2c5-5923-b58b-c145c04e99e2
DOI
10.1101/2022.01.13.476250
Open publication

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Naïve arthritogenic SKG T cells have a defect in anergy and a repertoire pruned by superantigenDOI 10.1101/2022.01.13.476250
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