Article
The endogenous repertoire harbors self-reactive CD4+ T cell clones that adopt a follicular helper T cell-like phenotype at steady state.
Nature immunology - 1 Mar 2023
Lee Victoria, Rodriguez Donald M, Ganci Nicole K, Zeng Sharon, Ai Junting, Chao Jaime L, Walker Matthew T, Miller Christine H, Klawon David E J, Schoenbach Mary H, Kennedy Domenick E, Maienschein-Cline Mark, Socci Nicholas D, Clark Marcus R, Savage Peter A
Abstract excerpt
The T cell repertoire of healthy mice and humans harbors self-reactive CD4+ conventional T (Tconv) cells capable of inducing autoimmunity. Using T cell receptor profiling paired with in vivo clonal analysis of T cell differentiation, we identified Tconv cell clones that are recurrently enriched in non-lymphoid organs following ablation of Foxp3+ regulatory T (Treg) cells. A subset of these clones was highly...
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